Tr?�a��c A�A?y, na??u khA?ng dA?ng kem, ng?�a�?i ta th?�a�?ng nghA� A�a??n phDa pha�? a��ng tiA?ma?�u thua?�t ta??o hA�nh A�a�? cha��ng lA?o hA?a, nh?�ng A�A?y lA� ma��t ph?�??ng phA?p nguy hia�?m vA� khA?ng an toA�n khi ma��t ng?�a�?i xa la?? va��i con dao A�a�? ma�� xa?� trA?n khuA?n ma?�t. Milwaukee Bucks May thay, gia�? A�A?y A�A? cA? cA?c ph?�??ng phA?p A�ia�?u tra�� tha?�m ma�? ma��i la??p A�a?�y khoa??ng tra��ng gia�?a cream bA?i da vA� dao ma��. CA?c ch?�??ng trA�nh cha��ng lA?o hA?a nA�y cA? tha�? lA�m cho pha?�u thua?�t ta??o hA�nh a�� ma��t tha�?i A�?�a�?c coi lA� lA�n sA?ng t?�??ng lai a�� tra�Y thA�nh dA� vA?ng.

Dermal fillers (cha??t A�a��n)

A??�a�?c cA?c bA?c sA� sa�� da�?ng A�a�? b??m cA?n cA?c na??p nhA?n, cha�?a sa??o, lA�m cA?ng mA?i ba?�ng cA?ch khA?i pha�?c kha��i l?�a�?ng vA� A�?�a�?ng nA�t. Air Jordan 4 Retro NA?i cA?ch khA?c lA� a�?tra?� hA?a daa�?.

Dermal filler A�?�a�?c lA�m ta�� nhia�?u nguyA?n lia��u. Ba??t ka�? loa??i filler nA�o A�?�a ra tha�� tr?�a�?ng cA�ng A�?�a�?c phA?n loa??i nh?� thia??t ba�� y ta?? vA� pha??i A�A?p a��ng cA?c yA?u ca?�u ca��a Medical Devices Directive (MDD) a�Y ChA?u A�u vA� tiA?u chua?�n FDA A�?�a�?c thA?ng qua ta??i Ma�?.

BA?c sA� tiA?m hA�ng loa??t mA�i filler lA?n vA?ng da vA� nha?? nhA�ng massage. Ba??n cA? tha�? ba�� s?�ng vA� A�au trong ma��t tha�?i gian nga??n sau khi tiA?m. Ma��t sa�� ph?�??ng phA?p ca?�n bA?i cream gA?y tA? hoa?�c tiA?m thua��c mA?. Tha�?i gian A�ia�?u tra�� cA? tha�? kA�o dA�i ta�� 30 phA?t a�� 1 gia�?. VA?ng da A�ia�?u tra�� cA? tha�? s?�ng vA� A�au trong vA?ng 24 gia�? vA� trong sua��t tha�?i gian nA�y ba??n ca?�n pha??i kiA?ng ua��ng cafA�, r?�a�?u, A�a�� ua��ng nA?ng, A�i na??ng.

Ma��t sa�� dermal filler A�?�a�?c la??y ta�� collagen, trong A�A? ma��t sa�� la??y ta�� collagen ca��a gia��ng bA?, ma��t sa�� la??y ta�� gia��ng la�?n. CA?c filler khA?c thA� lA�m ba?�ng nhA?n ta??o, A�?�a�?c cha?? ta??o trong phA?ng thA� nghia��m vA� A�?�a�?c la??y ta�� axit hialuronic. Nha�?ng filler A�?�a�?c la??y ta�� collagen vA� axit hialuronic lA� nha�?ng sa??n pha?�m thoA?i bia??n sinh ha�?c ta??m tha�?i, cA? nghA�a lA� ka??t qua?? tha?�m ma�? sa?? kA�o dA�i ta�� 3 a�� 12 thA?ng tA?y vA�o loa??i sa??n pha?�m vA� lia�?u l?�a�?ng sa�� da�?ng. Air Jordan 6 (VI) CA?c filler A�?�a�?c cha?? ta??o ta�� collagen th?�a�?ng A�A?i ha�?i pha??i kia�?m nghia��m lA?n da A�a�? xem cA? da�� a��ng hay khA?ng, nh?�ng cA?c filler A�?�a�?c lA�m ta�� axit hialuronic thA� khA?ng ca?�n. Ma��t sa�� nhA?n hia��u filler hia��n nay lA� RestylaneA�, HydrafillA�, JuvedermA� , RadiesseA�.

Collagen

Tr?�a��c A�A?y, ng?�a�?i ta cha�� sa�� da�?ng dermal filler A�a�? A�ia�?u tra��, sau A�A? lA� tiA?m collagen cA�ng gia??m da?�n sa��c thu hA?t khi A�?�a�?c gia��i thia��u ra tha�� tr?�a�?ng trong 10 nA?m qua. Utah State Aggies A?a��i va��i Evolence, ma��t loa??i collagen filler ma��i, ma��t phiA?n ba??n FDA ma��i A�?�a�?c thA?ng qua dA�i ga??p A�A?i, collagen nA�y cA? tha�? ta??o sa�� ha��i sinh. KhA?ng nh?� ng?�a�?i tia�?n nhia��m A�?�a�?c lA�m ba?�ng collagen theo cA?ng ngha�� sinh ha�?c ca��a ng?�a�?i vA� bA?, Evolence A�?�a�?c lA�m ta�� heo. NA? gia��ng collagen cA?a ng?�a�?i h??n lA� collagen ca��a bA?. Kanken 7L Do A�A?, khA?ng ca?�n kia�?m nghia��m tA�nh da�� a��ng th?�a��c vA� cA�ng khA?ng ba�� nhia��m a�?ba��nh bA? A�iA?na�?.

CA?ch hoa??t A�a��ng: Collagen chia??m khoa??ng 80% la��p na�?n ca��a da, ta��c lA� ha?? bA�. CA?c sa�?i collagen nA�y ba�� A�a��t gA?y theo tha�?i gian, nhA?n da ba??t A�a?�u xua??t hia��n lA�m cho da tra�Y nA?n la�?ng la?�o vA� lA?n xua��ng. TiA?m collagen thay vA�o kha��i l?�a�?ng A�A? ba�� ma??t, tA�ch ga��p la??i A�a�? lA�m ma??nh ma?? cho ka??t ca??u da vA� ta??o A�a�� lA?n ma��n.

CA?ch sa�� da�?ng: Trong khi phiA?n ba??n collagen cA� A�?�a�?c dA?ng cha�� ya??u cho nhA?n da, thA� Evolence la??i hia��u qua?? trong via��c pha�?c ha��i va��a pha??i kha��i l?�a�?ng A�A? ma??t cho nha�?ng na??p nhA?n, cha??ng ha??n nh?� na??p nhA?n xung quanh mA�i vA� mia��ng. Na??u Evolence Breeze A�?�a�?c thA?ng qua vA�o nA?m nay theo nh?� da�� kia??n, thA� phiA?n ba??n A�t nha��t nA�y sa?? mang la??i ma��t la��a cha�?n kha?? thi trong via��c cha��ng nhA?n da.

Ca??m ba?�y: Nha�?ng ca�?c u vA� nha�?ng cha�� s?�ng lA� nguy c?? ra??t cao, nh?�ng collagen ma�?m cA? tha�? A�?�a�?c massage cho tan ta??i n??i A�ia�?u tra�� na??u nh?� cha�� s?�ng A�A? xua??t hia��n ngay la?�p ta��c. Hoa?�c bA?c sA� sa?? chA�ch enzyme collagenase A�a�? lA�m tan chA?ng trong vA?ng 2 tua?�n.

Hia��u qua?? kA�o dA�i bao lA?u: Evolence hia��u qua?? trong vA?ng 6 a�� 12 thA?ng, trong khi cA?c sa??n pha?�m collagen khA?c, tr?�a��c A�A?y nh?� CosmoDerm and Zyderm cha�� kA�o dA�i 3 thA?ng.

Chi phA�: $500 hoa?�c cao h??n cho ma��i vA?ng da tra�� lia��u.

ThA?ng tin ta�� FDA: Evolence Porcine Collagen Dermal Filler A�?�a�?c sa??n xua??t ba�Yi Colbar Life Science vA� A�?�a�?c thA?ng qua vA�o nA?m 2008, ra?�ng: Evolence Collagen Filler lA� ma��t sa??n pha?�m tiA?m chA�ch A�a�? A�ia�?u cha��nh va��a pha??i cA?c na??p nhA?n trA?n ma?�t vA� na??p nhA?n a�Y mA�i.

MA? ta?? sa??n pha?�m: Evolence Collagen Filler lA� thia??t ba�� vA? trA?ng, khA?ng gA?y sa��t, a��n A�a��nh va��i pH sinh lA? cA? mA�u h??i vA�ng, A�a��ng nha??t, gel A�a�?c, A�?�a�?c A�A?ng gA?i sa?�n vA�o a��ng tiA?m. NA? bao ga��m 35mg/ml (A�5 mg/ml) collagen la�?n da??ng sa�?i loa??i I A�A? ba�� phA?n ha��y sinh ha�?c A�?�a�?c liA?n ka??t chA�o ba?�ng cA?ch sa�� da�?ng D-ribose l?? la�?ng trong mua��i phosphate A�a��m (PBS). Ra??t nhia�?u pha?�n khA?ng nguyA?n ca��a phA?n ta�� collagen A�A? ba�� la??y A�i.

Axit Hialuronic

LA� ma��t da??ng gel cA? ngua��n ga��c ta�� A�?�a�?ng, A�?�a�?c sa�� da�?ng ra��ng rA?i nha??t. Hia��n ta??i, Axit hialuronic (HA) bao ga��m cA?c tA?n Restylane, JuvA�derm, and Perlane.

CA?ch hoa??t A�a��ng: BA?c sA� tiA?m HA A�a�? ta??o thA?m A�?�a�?ng nA�t vA� lA�m cA?ng pha��ng cho da?? ba�� lA?n xua��ng, lA�m cho mA?i cA?ng ma��ng vA� lA�m lA?n na??p nhA?n.

CA?ch sa�� da�?ng: HA A�?�a�?c dA?ng A�a�? A�ia�?u tra�� va��a pha??i cA?c na??p nhA?n a�Y ma?�t, cha??ng ha??n nh?� na??p nhA?n a�Y vA?ng mA�i cha??y xua��ng vA?ng mia��ng. Tuy nhiA?n, A�a�� nha��t khA?c nhau ca��a nA? cho phA�p bA?c sA� sa�� da�?ng HA A�a�? lA�m cA?ng mA?i vA� trA?n, cA�ng nh?� ta??o A�?�a�?ng nA�t cho pha?�n quai hA�m. Ma��t sa�� bA?c sA� cA�ng cA? tha�? tiA?m vA�o nha�?ng vA?ng bA?n d?�a��i ma??t A�a�? bA? cho kha��i l?�a�?ng ma�? A�A? ma??t.

Ca??m ba?�y: S?�ng vA� ba?�m tA�m lA� nha�?ng tA?c da�?ng pha�? pha�� bia??n nha??t, th?�a�?ng kA�o dA�i khA?ng ta��i ma��t tua?�n. Na??u tiA?m HA khA?ng A�a�?u A�a?�n hoa?�c tiA?m quA? ca??n sa?? gA?y s?�ng, sa�� da�?ng quA? nhia�?u sa?? lA�m cho ba??n trA?ng nh?� b??m pha��ng hoa?�c bA� phA?.

Hia��u qua?? kA�o dA�i bao lA?u: HA filler cA�ng t?�??ng ta�� nh?� trA?n, ngoa??i tra�� tua��i tha�?. Ma��t mA�i tiA?m JuvA�derm kA�o dA�i A�a??n 1 nA?m. Trong khi ma��t tuyA?n ba�� ga?�n A�A?y ca��a cA?c Restylane ra?�ng nA? kA�o dA�i A�a??n 18 thA?ng. Ba??n ca?�n tiA?m la?�n 2 sau 6 thA?ng, ba�Yi vA� filler sa?? tan da?�n ga?�n ma��t na�?a l?�a�?ng tiA?m tiA?m ban A�a?�u.

Chi phA�: ta�� $600 A�a??n 1000$ cho ma��i vA?ng A�ia�?u tra��.

ThA?ng tin ta�� FDA: Gel tiA?m Restylane vA� gel tiA?m Perlane do Medicis Aesthetics Holdings, Inc. sa??n xua??t A�?�a�?c thA?ng qua vA�o nA?m 2005, ra?�ng: Restylane dA?ng tiA?m vA�o la��p da ta�� gia�?a A�a??n sA?u A�a�? A�ia�?u cha��nh va��a pha??i na??p nhA?n da ma?�t na?�ng. Perlane dA?ng A�a�? tiA?m vA�o sA?u bA?n trong da A�a�? A�ia�?u cha��nh va��a pha??i na??p nhA?n da ma?�t na?�ng.

MA? ta?? sa??n pha?�m: Restylane cA? cha��a axit hialuronic (HA), a��n A�a��nh, A�?�a�?c ta??o ba�Yi khua?�n liA?n ca?�u vA� cA? cA?ng tha��c na��ng A�a�� 20mg/ml, l?? la��ng trong ma��t ba�� A�a��m sinh lA? pH7. Restylane lA� ma��t loa??i gel vA? trA?ng, nha��t vA� trong sua��t A�?�a�?c cho vA�o a��ng tiA?m tha��y tinh sa�� da�?ng ma��t la?�n. a�?ng tiA?m nA�y A�?�a�?c A�A?ng gA?i trong ma��t va�� cA?ng va��i ma��t cA?y kim 30G vA? trA?ng. Baylor Bears Jerseys HA nA�y cA? tra�?ng l?�a�?ng phA?n ta�� khoa??ng 1 tria��u vA� A�?�a�?c a��n A�a��nh ba?�ng cA?ch thA?m ma��t l?�a�?ng nha�? BDDE (1,4 butanediol diglycidyl) A�a�? cho phA�p ta??o thA�nh ma??ng l?�a��i phA?n ta�� HA 3 chia�?u (gel). Perlane lA� ma��t loa??i gel axit hialuronic vA? trA?ng A�?�a�?c ta??o ba�Yi ma��t loa??i khua?�n liA?n ca?�u, cA? liA?n ka??t chA�o va��i BDDE, a��n A�a��nh vA� l?? la�?ng trong mua��i phosphate A�a��m pH=7, na��ng A�a�� 20mg/ml. PhA?n sa�� la��n nha??t ca��a kA�ch th?�a��c phA?n ta�� gel lA� ta�� 940 A�a??n 1090 micron.

MA? ca??y gel Juvederm (Juvederm 30, Juvederm 24HV, Juvederm 30HV) A�?�a�?c Allegan cha?? ta??o, A�?�a�?c thA?ng qua vA�o nA?m 2006 dA�nh cho: Juvederm 30, Juvederm 24HV, Juvederm 30HV lA� cA?c loa??i gel tiA?m dA?ng A�a�? tiA?m vA�o la��p da ta�� va��a A�a??n sA?u A�a�? A�ia�?u cha��nh va��a pha??i na??p nhA?n da ma?�t na?�ng (cha??ng ha??n nh?� na??p nhA?n a�Y vA?ng mA�i). MA? ta?? sa??n pha?�m: Gel tiA?m JUVEDERM lA� ma��t loa??i mA? ca??y gel A�A? A�?�a�?c A�a��ng nha??t, khA?ng mA�u, trong sua��t, nha��t, khA?ng gA?y sa��t, phA?n ha��y sinh ha�?c vA� vA? trA?ng. JUVEDERM cA? cha��a axit hialuronic liA?n ka??t chA�o (HA), cA? cA?ng tha��c na��ng A�a�� 22 a�� 26mg/ml, l?? la��ng trong ba�� A�a��m sinh ha�?c. HA trong JUVEDERM A�?�a�?c ta??o ba�Yi khua?�n equi liA?n ca?�u. HA A�?�a�?c sa�� da�?ng trong JUVEDERM cA? tra�?ng l?�a�?ng phA?n ta�� xa??p xa�� ba?�ng 2.5 tria��u Dalton vA� A�?�a�?c liA?n ka??t chA�o ba?�ng cA?ch thA?m ma��t l?�a�?ng nha�? BDDE A�a�? ta??o thA�nh gel HA 3 chia�?u.

JUVEDERM hia��n A�ang cA? va��i 3 cA?ng tha��c (30, 24HV vA� 30HV) vA� A�?�a�?c b??m sa?�n trong cA?c a��ng tiA?m. Juvederm 30HV lA� cA?ng tha��c ma??nh, cA? liA?n ka??t chA�o cao h??n. Sa�� da�?ng kim 27G tiA?m vA� A�ia�?u cha��nh cA?c na??p nhA?n sA?u bA?n trong.

Juvederm 24HV lA� ma��t cA?ng tha��c liA?n ka??t chA�o cao cA? tha�? sa�� da�?ng kim 30G A�a�? tiA?m nha?�m ta??o tA�nh linh hoa??t h??n trong via��c ta??o A�?�a�?ng nA�t vA� gia??m nhA?n da trA?n ma?�t. Juvederm 30 cA�ng lA� cA?ng tha��c chA�o cao, sa�� da�?ng kim 27G A�a�? tiA?m, dA?ng A�ia�?u cha��nh tA�nh ta?? cA?c na??p nhA?n trA?n ma?�t.

cha??t A�a��n ta��ng ha�?p

Collagen thua��c loa??i nA�y bao ga��m Sculptra vA� Radiesse.

CA?ch hoa??t A�a��ng: Ca?? hai A�a�?u thA?c A�a?�y c?? tha�? ta??o collagen. Radiesse A�?�a�?c lA�m ba?�ng vi ca?�u cA? ga��c canxi l?? la��ng trong gel, lA�m cA?ng pha��ng da liA?n ta�?c. Sculptra (poly-L-lactic acid) thA� pha??i ma??t vA�i thA?ng ma��i cA? hia��u qua?? vA� nA? da��a vA�o c?? tha�? ba??n A�a�? cA? thA?m collagen.

CA?ch sa�� da�?ng: Ca?? hai A�a�?u hia��u qua?? nha??t trong via��c b??m vA�o cA?c na??p nhA?n a�Y xung quanh mia��ng, hoa?�c A�a�? lA?t vA�o gA? mA? ba�� ha��p. Ca??m ba?�y: Ba�Yi vA� Sculptra khA?ng cho ka??t qua?? nhA�n tha??y ngay la?�p ta��c, nA?n bA?c sA� yA?u ca?�u ba??n tA?i khA?m nhia�?u la?�n h??n. BA?n ca??nh A�A?, nha�?ng ca�?c u nha�? cA? tha�? xua??t hia��n, A�a?�c bia��t lA� na??u ba??n tiA?m Radiesse quA? ca??n. Do A�A?, ba??n nA?n trA?nh tiA?m hai loa??i nA�y a�Y nha�?ng vA?ng da ma�?ng, nh?� xung quanh ma??t.

Hia��u qua?? kA�o dA�i bao lA?u: Radiesse kA�o dA�i 1 nA?m hoa?�c lA?u h??n, Sculptra thA� kA�o dA�i 2 nA?m.

Chi phA�: Radiesse giA? khoa??ng $800, Sculptra khoa??ng $1.000

ThA?ng tin ta�� FDA: Sculptra do Sanofi Aventis Pharmaceuticals, Inc. cha?? ta??o, A�?�a�?c thA?ng qua vA�o nA?m 2004, ra?�ng: Sculptra dA?ng A�a�? pha�?c ha��i hoa?�c/vA� A�ia�?u cha��nh cA?c da??u hia��u ma??t ma�? trA?n khuA?n ma?�t (lipoatrophy) a�Y nha�?ng ng?�a�?i cA? hoa?�c tia??p nha?�n A�ia�?u tra�� suy gia??m mia��n da��ch virus a�Y ng?�a�?i.

MA? ta?? sa??n pha?�m: Sculptra lA� ma��t loa??i mA? ca??y poly-L-lactic acid tiA?m cA? hA�nh da??ng ma��t chia??c bA?nh A�A?ng khA? vA? trA?ng. Sculptra cA? cha��a cA?c vi ha??t poly-L-lactic acid, ma��t ta��ng ha�?p cha??t trA?ng ha�?p, phA?n ha��y sinh ha�?c, t?�??ng ha�?p sinh ha�?c ta�� gia A�A�nh alpha-hydroxy-acid. Sculptra A�?�a�?c tA?i ta??o tr?�a��c khi sa�� da�?ng ba?�ng cA?ch thA?m n?�a��c vA? khua?�n A�a�? tiA?m, USP ( SWFI) A�a�? ta??o thA�nh ma��t tha�? va?�n vA? trA?ng, khA?ng gA?y sa��t.

Radiesse do Bioform Medical, Inc. sa??n xua??t, A�?�a�?c thA?ng qua vA�o nA?m 2006, ra?�ng: Radiesse A�?�a�?c dA?ng A�a�? ca??y vA�o d?�a��i da A�a�? A�ia�?u cha��nh va��a pha??i cA?c na??p nhA?n trA?n khuA?n ma?�t.

MA? ta?? sa??n pha?�m: Radiesse lA� ma��t loa??i mA? ca??y dA�nh, bA?n kiA?n ca��, khA?ng gA?y sa��t vA� vA? trA?ng. ThA�nh pha?�n cha�� ya??u lA� hydroxylapatite canxi ta��ng ha�?p (CaHA) l?? la��ng trong bA�nh gel n?�a��c vA? trA?ng dA?ng A�a�? tiA?m, glycerin vA� Natri carboxymethylcellulose. Radiesse (1.3 cc vA� 0.3 cc) cA? kA�ch th?�a��c phA?n ta�� CaHA ta�� 25 a�� 45 micron vA� A�?�a�?c tiA?m va��i kim 25 a�� 27G.

Kia�?m tra tA�nh an toA�n

KhA?ng hoA�n toA�n tr??n tru trong tha?? gia��i filler tiA?m cha��ng nhA?n da. Toronto Raptors Ma��t ba??ng FDA xem xA�t tA�nh an toA�n ca��a via��c tiA?m trong tha�?i gian ga?�n A�A?y A�A? kA?u ga�?i ca??nh bA?o vA� kia�?m nghia��m thA?m ta??t ca?? cA?c filler tha?�m ma�?, sau khi cA? ga?�n 1.000 tr?�a�?ng ha�?p tA?c da�?ng ng?�a�?c A�?�a�?c bA?o cA?o ta��

Da pha�?

nA?m 2003 a�� 2008 (ta�� s?�ng na?�ng cho A�a??n sa??o vA�nh via��n). Ha?�u ha??t cA?c

va??n A�a�? lA� do ka??t qua?? ca��a via��c sa�� da�?ng khA?ng A�A?ng (tiA?m

vA�o nha�?ng lA�nh va��c ch?�a A�?�a�?c FDA thA?ng qua ca�? tha�?).

FDA cha��ng cha�� A�a��nh sa�� da�?ng:

Ta??t ca?? cA?c dermal filler A�a�?u cha��ng cha�� A�a��nh cho ba��nh nhA?n cA?:

  • Nha??y ca??m va��i ba??t ka�? thA�nh pha?�n nA�o ca��a filler.
  • Tia�?n sa�� da�� a��ng hoa?�c ma?�n ca??m.
  • Ra��i loa??n cha??y mA?u.

FDA ca??nh bA?o vA� phA?ng nga��a

NhA�n chung, cA?c ca??nh bA?o vA� phA?ng nga��a d?�a��i A�A?y A�a�?u A?p da�?ng cho ta??t ca?? cA?c dermal filler. CA? ma��t sa�� ca??nh bA?o ba�� sung cA? tha�? lA� liA?n quan A�a??n thA�nh pha?�n cha??t lia��u da�?ng ca�?.

  • TrA?nh tiA?m vA�o ma??ch mA?u ba�Yi vA� ta??c ngha??n ma??ch mA?u (vA� cA? tha�? lA� sau nA�y mA? hoa??i ta��) cA? tha�? xa??y ra.
  • Ng?�ng tiA?m cho A�a??n khi nhia��m trA?ng hoa?�c viA?m A�A? kha�?i
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